Why the Energy Landscape of Barnase Is Hierarchical

Why the Energy Landscape of Barnase Is Hierarchical

We have used NMR and computational methods to characterize the dynamics of the ribonuclease barnase over a wide range of timescales in free and inhibitor-bound states. Using temperature- and denaturant-dependent measurements of chemical shift, we show that barnase undergoes frequent and highly popul...

Full description

Bibliographic Details
Main Authors: Maya J. Pandya, Stefanie Schiffers, Andrea M. Hounslow, Nicola J. Baxter, Mike P. Williamson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein dynamics
nuclear magnetic resonance (NMR)
biophysics
structural biology
molecular dynamics
conformational selection
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00115/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2018.00115/full

Similar Items