Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance

Characteristics of Cohesin Mutation in Acute Myeloid Leukemia and Its Clinical Significance

The occurrence of gene mutation is a major contributor to the initiation and propagation of acute myeloid leukemia (AML). Accumulating evidence suggests that genes encoding cohesin subunits have a high prevalence of mutations in AML, especially in the t(8;21) subtype. Therefore, it is important to u...

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Bibliographic Details
Main Authors: Caixia Han, Xuefeng Gao, Yonghui Li, Juan Zhang, Erna Yang, Li Zhang, Li Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Oncology
Subjects:
cohesin mutation
acute myeloid leukemia
AML1-ETO
hematopoietic stem and progenitor cells
leukemogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.579881/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.579881/full

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