Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes

Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes

Interleukin (IL)-1β is an important pro-inflammatory cytokine in the progression of osteoarthritis (OA), which impairs mitochondrial function and induces the production of nitric oxide (NO) in chondrocytes. The aim was to investigate if blockade of NO production prevents IL-1β-induced mitochondrial...

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Bibliographic Details
Main Authors: Annett Eitner, Sylvia Müller, Christian König, Arne Wilharm, Rebecca Raab, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
NO synthase
Interleukin-1β
chondrocytes
mitochondrial dysfunction
Online Access:https://www.mdpi.com/1422-0067/22/5/2477

Internet

https://www.mdpi.com/1422-0067/22/5/2477

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