Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes
Interleukin (IL)-1β is an important pro-inflammatory cytokine in the progression of osteoarthritis (OA), which impairs mitochondrial function and induces the production of nitric oxide (NO) in chondrocytes. The aim was to investigate if blockade of NO production prevents IL-1β-induced mitochondrial...
Main Authors: | Annett Eitner, Sylvia Müller, Christian König, Arne Wilharm, Rebecca Raab, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/5/2477 |
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