Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells

Understanding the global metabolic changes during the senescence of tumor cells can have implications for developing effective anti-cancer treatment strategies. Ionizing radiation (IR) was used to induce senescence in a human colon cancer cell line HCT-116 to examine secretome and metabolome profile...

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Bibliographic Details
Main Authors: Chandrasekharam N. Nagineni, Sarwat Naz, Rajani Choudhuri, Gadisetti V. R. Chandramouli, Murali C. Krishna, Jeffrey R. Brender, John A. Cook, James B. Mitchell
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
senescence
colon cancer
HCT-116
ionizing radiation
secretome
metabolic pathways
Online Access:https://www.mdpi.com/1422-0067/22/9/4835

Internet

https://www.mdpi.com/1422-0067/22/9/4835

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