In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development

In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development

At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos depend on their own drug-metabolizing capacity, knowledge of their intrinsic biotransformation is pivotal in order to corre...

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Bibliographic Details
Main Authors: Evy Verbueken, Derek Alsop, Moayad A. Saad, Casper Pype, Els M. Van Peer, Christophe R. Casteleyn, Chris J. Van Ginneken, Joanna Wilson, Steven J. Van Cruchten
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
zebrafish
embryo
development
cytochrome P450
activity
in vitro
and biotransformation
Online Access:http://www.mdpi.com/1422-0067/18/1/217

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http://www.mdpi.com/1422-0067/18/1/217

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