Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients.

Impact of glutathione S-transferase M1 and T1 on anti-tuberculosis drug-induced hepatotoxicity in Chinese pediatric patients.

BACKGROUND:Anti-tuberculosis drug induced hepatotoxicity (ATDH) is a major adverse drug reaction associated for anti-tuberculosis therapy. The glutathione S-transferases (GST) plays a crucial role in the detoxification of hepatotoxic metabolites of anti-tuberculosis drugs.An association between GSTM...

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Main Authors: Fang Liu, An-xia Jiao, Xi-rong Wu, Wei Zhao, Qing-qin Yin, Hui Qi, Wei-wei Jiao, Jing Xiao, Lin Sun, Chen Shen, Jian-ling Tian, Dan Shen, Evelyne Jacqz-Aigrain, A-dong Shen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4272297?pdf=render

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http://europepmc.org/articles/PMC4272297?pdf=render

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