Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Tafazzin Mutation Affecting Cardiolipin Leads to Increased Mitochondrial Superoxide Anions and Mitophagy Inhibition in Barth Syndrome

Tafazzin is a phospholipid transacylase that catalyzes the remodeling of cardiolipin, a mitochondrial phospholipid required for oxidative phosphorylation. Mutations of the tafazzin gene cause Barth syndrome, which is characterized by mitochondrial dysfunction and dilated cardiomyopathy, leading to p...

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Bibliographic Details
Main Authors: Patrice X. Petit, Hector Ardilla-Osorio, Lucile Penalvia, Rainey Nathan E.
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
Barth syndrome
mitochondria
cardiolipin
autophagy
apoptosis
electron transport
Online Access:https://www.mdpi.com/2073-4409/9/10/2333

Internet

https://www.mdpi.com/2073-4409/9/10/2333

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