Enhanced skin permeation of Methotrexate from penetration enhancer containing vesicles: In vitro optimization and in vivo evaluation

Enhanced skin permeation of Methotrexate from penetration enhancer containing vesicles: In vitro optimization and in vivo evaluation

Low dose Methotrexate (MTX) therapy is considered a gold standard for Rheumatoid Arthritis (RA). Transdermal drug delivery is hypothesized as an alternative to conventional therapies to alleviate its adverse effects. In our study, MTX was entrapped in deformable liposomes and loaded in a hydroxyethy...

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Bibliographic Details
Main Authors: Bhakti Sadarani, Anuradha Majumdar, Shalaka Paradkar, Anupam Mathur, Satbir Sachdev, Bhabani Mohanty, Pradip Chaudhari
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Biodistribution
Methotrexate
Labrasol
Oleic acid
Transdermal delivery
Rheumatoid Arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218348893

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http://www.sciencedirect.com/science/article/pii/S0753332218348893

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