MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

MR1-Restricted MAIT Cells From The Human Lung Mucosal Surface Have Distinct Phenotypic, Functional, and Transcriptomic Features That Are Preserved in HIV Infection

Mucosal associated invariant T (MAIT) cells are a class of innate-like T cells that utilize a semi-invariant αβ T cell receptor to recognize small molecule ligands produced by bacteria and fungi. Despite growing evidence that immune cells at mucosal surfaces are often phenotypically and functionally...

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Bibliographic Details
Main Authors: Sharon Khuzwayo, Maphe Mthembu, Erin W. Meermeier, Sanjay M. Prakadan, Samuel W. Kazer, Thierry Bassett, Kennedy Nyamande, Dilshaad Fakey Khan, Priya Maharaj, Mohammed Mitha, Moosa Suleman, Zoey Mhlane, Dirhona Ramjit, Farina Karim, Alex K. Shalek, David M. Lewinsohn, Thumbi Ndung’u, Emily B. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
mucosal associated invariant T cells
lung mucosal immunity
tuberculosis
HIV
single-cell transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.631410/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.631410/full

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