Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

Abstract For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein B...

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Bibliographic Details
Main Authors: Lena Will, Sybren Portegies, Jasper van Schelt, Merel van Luyk, Dick Jaarsma, Casper C. Hoogenraad
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Acta Neuropathologica Communications
Subjects:
BICD2
Radial neuronal migration
Neocortical development
Dynein adaptor
Online Access:http://link.springer.com/article/10.1186/s40478-019-0827-y

Internet

http://link.springer.com/article/10.1186/s40478-019-0827-y

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