IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

IgG anti-hinge antibodies against IgG4 F(ab’)2 fragments generated using pepsin are useful diagnostic markers for rheumatoid arthritis: implications of the possible roles of metalloproteinases and IgG subclasses in generating immunogenic hinge epitopes

Abstract Background Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each hinge epitope generated by each protease that cleaves the hinge region...

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Bibliographic Details
Main Authors: Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino, Shuji Nagano
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Arthritis Research & Therapy
Subjects:
Anti-hinge antibody
Matrix metalloproteinase
IgG4
Rheumatoid factor
ACPA
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02251-7

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http://link.springer.com/article/10.1186/s13075-020-02251-7

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