Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. MPLA is the product of chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2017-05-01
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Series: | mBio |
Online Access: | http://mbio.asm.org/cgi/content/full/8/3/e00492-17 |