Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells

Mechanism Governing Human Kappa-Opioid Receptor Expression under Desferrioxamine-Induced Hypoxic Mimic Condition in Neuronal NMB Cells

Cellular adaptation to hypoxia is a protective mechanism for neurons and relevant to cancer. Treatment with desferrioxamine (DFO) to induce hypoxia reduced the viability of human neuronal NMB cells. Surviving/attached cells exhibited profound increases of expression of the human kappa-opioid recepto...

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Bibliographic Details
Main Authors: Jennifer Babcock, Alberto Herrera, George Coricor, Christopher Karch, Alexander H. Liu, Aida Rivera-Gines, Jane L. Ko
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
desferrioxamine
hypoxia
hypoxia inducible factor-1α
human kappa-opioid receptor
HIF response elements
human NMB neuronal cells
Online Access:http://www.mdpi.com/1422-0067/18/1/211

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http://www.mdpi.com/1422-0067/18/1/211

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