HIV-Infected Patients Developing Tuberculosis Disease Show Early Changes in the Immune Response to Novel Mycobacterium tuberculosis Antigens

HIV-Infected Patients Developing Tuberculosis Disease Show Early Changes in the Immune Response to Novel Mycobacterium tuberculosis Antigens

Background: In individuals living with HIV infection the development of tuberculosis (TB) is associated with rapid progression from asymptomatic TB infection to active TB disease. Sputum-based diagnostic tests for TB have low sensitivity in minimal and subclinical TB precluding early diagnosis. The...

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Bibliographic Details
Main Authors: Noemi Rebecca Meier, Manuel Battegay, Tom H. M. Ottenhoff, Hansjakob Furrer, Johannes Nemeth, Nicole Ritz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
T cell response
IGRA
RV
IP-10
TNF-alpha
Mycobacterium tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.620622/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.620622/full

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