Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis.

Circulating angiopoietin-2 as a biomarker in ANCA-associated vasculitis.

The endothelial-specific Angiopoietin-Tie2 ligand-receptor system is an important regulator of endothelial activation. Binding of angiopoietin-2 (Ang-2) to Tie2 receptor renders the endothelial barrier responsive to pro-inflammatory cytokines. We previously showed that circulating Ang-2 correlated w...

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Bibliographic Details
Main Authors: Paul A Monach, Philipp Kümpers, Alexander Lukasz, Gunnar Tomasson, Ulrich Specks, John H Stone, David Cuthbertson, Jeffrey Krischer, Simon Carette, Linna Ding, Gary S Hoffman, David Iklé, Cees G M Kallenberg, Nader A Khalidi, Carol A Langford, Philip Seo, E William St Clair, Robert Spiera, Nadia Tchao, Steven R Ytterberg, Marion Haubitz, Peter A Merkel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261176?pdf=render

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http://europepmc.org/articles/PMC3261176?pdf=render

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