TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b

Despite improvements in diagnosis and treatment, breast cancer is still the most common cancer type among non-smoking females. TGF-β can inhibit breast cancer development by inducing cell cycle arrest in both, cancer cells and, as part of a senescence program in normal human mammary epithelial cells...

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Bibliographic Details
Main Authors: Catharina Melzer, Juliane von der Ohe, Ralf Hass, Hendrik Ungefroren
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer
HMEC
cell cycle arrest
senescence
transforming growth factor-β
Online Access:https://www.mdpi.com/1422-0067/18/7/1574

Internet

https://www.mdpi.com/1422-0067/18/7/1574

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