HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.

Despite significant progress in the cancer field, tumor cell invasion and metastasis remain a major clinical challenge. Cell invasion across tissue boundaries depends largely on extracellular matrix degradation, which can be initiated by formation of actin-rich cell structures specialized in matrix...

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Bibliographic Details
Main Authors: Dominique Arsenault, Karine Brochu-Gaudreau, Martine Charbonneau, Claire M Dubois
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566011?pdf=render