ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

The histone methyltransferase SETDB1 plays a central role in repressive chromatin processes, but the functional requirement for its binding partner ATF7IP has remained enigmatic. Here, we show that ATF7IP is essential for SETDB1 stability: nuclear SETDB1 protein is degraded by the proteasome upon ab...

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Bibliographic Details
Main Authors: Richard T. Timms, Iva A. Tchasovnikarova, Robin Antrobus, Gordon Dougan, Paul J. Lehner
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
heterochromatin
epigenetic silencing
histone methylation
H3K9me3
SETDB1
HUSH complex
ATF7IP
ubiquitin-mediated degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471631289X

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http://www.sciencedirect.com/science/article/pii/S221112471631289X

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