Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

The small molecules, natural antioxidant Caffeic Acid (trans-3,4-Dihydroxycinnamic acid CA) and anti-diabetic drug Metformin (Met), activate 5′-adenosine monophosphate-activated protein kinase (AMPK) and interfere with metabolic reprogramming in human cervical squamous carcinoma cells. Her...

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Bibliographic Details
Main Authors: Malgorzata Tyszka-Czochara, Karolina Bukowska-Strakova, Kinga A. Kocemba-Pilarczyk, Marcin Majka
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Nutrients
Subjects:
cancer metabolism
metabolic reprogramming
cervical cancer
Warburg effect
5′-adenosine monophosphate-activated protein kinase (AMPK)
Caffeic Acid
Metformin
polyphenols
mitochondria
Online Access:http://www.mdpi.com/2072-6643/10/7/841

Internet

http://www.mdpi.com/2072-6643/10/7/841

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