Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease

Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease

Mutations in KDM5C gene are linked to X-linked mental retardation, the syndromic Claes-Jensen-type disease. This study focuses on non-synonymous mutations in the KDM5C ARID domain and evaluates the effects of two disease-associated missense mutations (A77T and D87G) and three not-yet-classified miss...

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Bibliographic Details
Main Authors: Yunhui Peng, Jimmy Suryadi, Ye Yang, Tugba G. Kucukkal, Weiguo Cao, Emil Alexov
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
X-linked syndromic Claes-Jensen type disease
sequence variants
folding free energy changes
binding free energy changes
molecular dynamics
free energy perturbation
Online Access:http://www.mdpi.com/1422-0067/16/11/26022

Internet

http://www.mdpi.com/1422-0067/16/11/26022

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