Methylated DNA is over-represented in whole-genome bisulfite sequencing data

Methylated DNA is over-represented in whole-genome bisulfite sequencing data

The development of whole-genome bisulfite sequencing (WGBS) has led to a number of exciting discoveries about the role of DNA methylation leading to a plethora of novel testable hypotheses. Methods for constructing sodium bisulfite-converted and amplified libraries have recently advanced to the poin...

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Bibliographic Details
Main Authors: Lexiang eJi, Takahiko eSasaki, Xiaoxiao eSun, Ping eMa, Zachary A Lewis, Robert J Schmitz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Genetics
Subjects:
DNA Methylation
Epigenomics
epigenetics
Whole genome bisulfite sequencing
PCR Bias
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00341/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00341/full

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