Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).

Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).

BACKGROUND:Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. Repeated doses of PZQ at short intervals might increase efficacy in terms of cure rate (CR) and intensity reduction rate (I...

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Bibliographic Details
Main Authors: Pytsje T Hoekstra, Miriam Casacuberta-Partal, Lisette van Lieshout, Paul L A M Corstjens, Roula Tsonaka, Rufin K Assaré, Kigbafori D Silué, Aboulaye Meité, Eliézer K N'Goran, Yves K N'Gbesso, Abena S Amoah, Meta Roestenberg, Stefanie Knopp, Jürg Utzinger, Jean T Coulibaly, Govert J van Dam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008189

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https://doi.org/10.1371/journal.pntd.0008189

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