Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).
BACKGROUND:Preventive chemotherapy with praziquantel (PZQ) is the cornerstone of schistosomiasis control. However, a single dose of PZQ (40 mg/kg) does not cure all infections. Repeated doses of PZQ at short intervals might increase efficacy in terms of cure rate (CR) and intensity reduction rate (I...
Main Authors: | Pytsje T Hoekstra, Miriam Casacuberta-Partal, Lisette van Lieshout, Paul L A M Corstjens, Roula Tsonaka, Rufin K Assaré, Kigbafori D Silué, Aboulaye Meité, Eliézer K N'Goran, Yves K N'Gbesso, Abena S Amoah, Meta Roestenberg, Stefanie Knopp, Jürg Utzinger, Jean T Coulibaly, Govert J van Dam |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-03-01
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Series: | PLoS Neglected Tropical Diseases |
Online Access: | https://doi.org/10.1371/journal.pntd.0008189 |
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