Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

<p>Abstract</p> <p>Background</p> <p>The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, current single agent receptor targeting does not achieve a maximal therapeutic effect, and some mutations c...

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Bibliographic Details
Main Authors: Chen Gang, Kronenberger Peter, Teugels Erik, Umelo Ijeoma, De Grève Jacques
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Medicine
Subjects:
EGFR
RNA interference
tyrosine kinase inhibitors (TKIs)
anti-EGFR monoclonal antibodies (mAbs)
proliferation
apoptosis
lung cancer
Online Access:http://www.biomedcentral.com/1741-7015/10/28

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http://www.biomedcentral.com/1741-7015/10/28

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