Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities

Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities

Analogues or isosteres of α,γ-diketoacid (DKA) 1a show potent inhibition of hepatitis C virus (HCV) NS5B polymerase through chelation of the two magnesium ions at the active site. The anti-HCV activity of the flavonoid quercetin (2) could partly be attributed to it being a structural mimic of DKAs....

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Bibliographic Details
Main Authors: Dongwei Zhong, Mingming Liu, Yang Cao, Yelin Zhu, Shihui Bian, Jiayi Zhou, Fengjie Wu, Kum-Chol Ryu, Lu Zhou, Deyong Ye
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Molecules
Subjects:
anti-HCV activities
diketoacids mimic
quercetin derivatives
synthesis
docking
Online Access:http://www.mdpi.com/1420-3049/20/4/6978

Internet

http://www.mdpi.com/1420-3049/20/4/6978

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