Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice

Mucosal Exposure to Cigarette Components Induces Intestinal Inflammation and Alters Antimicrobial Response in Mice

The main environmental risk factor associated with the development of Crohn's disease (CD) is cigarette smoking. Although the mechanism is still unknown, some studies have shown that cigarette exposure affects the intestinal barrier of the small bowel. Among the factors that may be involved in...

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Bibliographic Details
Main Authors: Loni Berkowitz, Catalina Pardo-Roa, Geraldyne A. Salazar, Francisco Salazar-Echegarai, José P. Miranda, Gigliola Ramírez, José L. Chávez, Alexis M. Kalergis, Susan M. Bueno, Manuel Álvarez-Lobos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
cigarette smoking
Paneth cells
Crohn's disease
inflammatory bowel disease
antimicrobial peptides
microbiota
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02289/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02289/full

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