1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

Abstract Background Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon receptor (AHR). AHR is an important target for carcinogens, but its associ...

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Bibliographic Details
Main Authors: Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho, Humberto Dellê
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
Aryl hydrocarbon receptor
Indoleamine 2, 3-dioxygenase
Bladder cancer
Cytochrome P450 enzymes
Online Access:http://link.springer.com/article/10.1186/s12885-020-07371-6

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http://link.springer.com/article/10.1186/s12885-020-07371-6

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