PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness

Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological targeting of PAF reduces mammosphere formation.

Bibliographic Details
Main Authors: Xin Wang, Youn-Sang Jung, Sohee Jun, Sunhye Lee, Wenqi Wang, Andrea Schneider, Young Sun Oh, Steven H. Lin, Bum-Joon Park, Junjie Chen, Khandan Keyomarsi, Jae-Il Park
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10633

Internet

https://doi.org/10.1038/ncomms10633

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