A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of <i>URAT1/SLC22A12</i> among 30,685 Japanese Individuals

A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of <i>URAT1/SLC22A12</i> among 30,685 Japanese Individuals

Background: Renal hypouricemia (RHUC) is characterized by a low serum uric acid (SUA) level and high fractional excretion of uric acid (FE<sub>UA</sub>). Further studies on FE<sub>UA</sub> in hypouricemic individuals are needed for a more accurate diagnosis of RHUC. Methods:...

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Main Authors: Yusuke Kawamura, Akiyoshi Nakayama, Seiko Shimizu, Yu Toyoda, Yuichiro Nishida, Asahi Hishida, Sakurako Katsuura-Kamano, Kenichi Shibuya, Takashi Tamura, Makoto Kawaguchi, Satoko Suzuki, Satoko Iwasawa, Hiroshi Nakashima, Rie Ibusuki, Hirokazu Uemura, Megumi Hara, Kenji Takeuchi, Tappei Takada, Masashi Tsunoda, Kokichi Arisawa, Toshiro Takezaki, Keitaro Tanaka, Kimiyoshi Ichida, Kenji Wakai, Nariyoshi Shinomiya, Hirotaka Matsuo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
<i>URAT1/SLC22A12</i>
renal hypouricemia (RHUC)
serum uric acid (SUA)
fractional excretion of uric acid (FE<sub>UA</sub>)
Online Access:https://www.mdpi.com/2227-9059/9/8/1012

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https://www.mdpi.com/2227-9059/9/8/1012

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