Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy.

Resistance-Associated NS5A Variants of Hepatitis C Virus Are Susceptible to Interferon-Based Therapy.

The presence of resistance-associated variants (RAVs) of hepatitis C virus (HCV) attenuates the efficacy of direct acting antivirals (DAAs). The objective of this study was to characterize the susceptibility of RAVs to interferon-based therapy.Direct and deep sequencing were performed to detect Y93H...

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Bibliographic Details
Main Authors: Jun Itakura, Masayuki Kurosaki, Mayu Higuchi, Hitomi Takada, Natsuko Nakakuki, Yoshie Itakura, Nobuharu Tamaki, Yutaka Yasui, Shoko Suzuki, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yuka Takahashi, Shinya Maekawa, Nobuyuki Enomoto, Namiki Izumi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4569333?pdf=render

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http://europepmc.org/articles/PMC4569333?pdf=render

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