HUMAN NK CELLS: FROM SURFACE RECEPTORS TO THE THERAPY OF LEUKEMIAS AND SOLID TUMORS

HUMAN NK CELLS: FROM SURFACE RECEPTORS TO THE THERAPY OF LEUKEMIAS AND SOLID TUMORS

Natural Killer (NK) cells are major effector cells of the innate immunity. The discovery, over two decades ago, of MHC-class I specific NK receptors and subsequently of activating receptors, recognizing ligands expressed by tumor or virus-infected cells, paved the way to our understanding of the mec...

Full description

Bibliographic Details
Main Authors: LORENZO eMORETTA, Gabriella ePietra, Elisa eMontaldo, Paola eVacca, Daniela ePende, Michela eFalco, Genny eDel Zotto, Franco eLocatelli, Alessandro eMoretta, Maria Cristina eMingari
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Immunology
Subjects:
Hematopoietic Stem Cell Transplantation
Tumor Microenvironment
NK cells
alloreactive NK cells
Killer Ig-like receptors
Activating NK receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00087/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00087/full

Similar Items