Assessment of PEEP-Ventilation and the Time Point of Parallel-Conductance Determination for Pressure-Volume Analysis Under β-Adrenergic Stimulation in Mice

Assessment of PEEP-Ventilation and the Time Point of Parallel-Conductance Determination for Pressure-Volume Analysis Under β-Adrenergic Stimulation in Mice

Aim: Cardiac pressure-volume (PV loop) analysis under β-adrenergic stimulation is a powerful method to simultaneously determine intrinsic cardiac function and β-adrenergic reserve in mouse models. Despite its wide use, several key approaches of this method, which can affect murine cardiac function t...

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Bibliographic Details
Main Authors: Lucas Bacmeister, Sebastian Segin, Rebekka Medert, Diana Lindner, Marc Freichel, Juan E. Camacho Londoño
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
pressure-volume analysis
parallel-conductance
β-adrenergic stimulation
hypertonic saline
positive end-expiratory pressure
end-systolic pressure-spikes
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00036/full

Internet

https://www.frontiersin.org/article/10.3389/fcvm.2019.00036/full

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