Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy

Measurement of the Interaction Between Recombinant I-domain from Integrin alpha 2 beta 1 and a Triple Helical Collagen Peptide with the GFOGER Binding Motif Using Molecular Force Spectroscopy

The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane receptor, alpha 2 beta 1, responsible for firm attach...

Full description

Bibliographic Details
Main Authors: Mark E. Welland, Richard W. Farndale, Dominique Bihan, Debdulal Roy, Simon J. Attwood, Anna M. C. Simpson, Samir W. Hamaia
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
integrin
alpha 2 beta 1
collagen
atomic force microscopy
single moleculeforce spectroscopy
Online Access:http://www.mdpi.com/1422-0067/14/2/2832

Internet

http://www.mdpi.com/1422-0067/14/2/2832

Similar Items