T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current primary CLL xenograft models suffer from limited duration of tumour cell en...

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Bibliographic Details
Main Authors: Ceri E. Oldreive, Anna Skowronska, Nicholas J. Davies, Helen Parry, Angelo Agathanggelou, Sergey Krysov, Graham Packham, Zbigniew Rudzki, Laura Cronin, Katerina Vrzalikova, Paul Murray, Elena Odintsova, Guy Pratt, A. Malcolm R. Taylor, Paul Moss, Tatjana Stankovic
Format: Article
Language:English
Published: The Company of Biologists 2015-11-01
Series:Disease Models & Mechanisms
Subjects:
CLL
Mouse model
T-cell depletion
Online Access:http://dmm.biologists.org/content/8/11/1401

Internet

http://dmm.biologists.org/content/8/11/1401

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