Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat.

Epigenetic priming of AML blasts for all-trans retinoic acid-induced differentiation by the HDAC class-I selective inhibitor entinostat.

All-trans retinoic acid (ATRA) has only limited single agent activity in AML without the PML-RARα fusion (non-M3 AML). In search of a sensitizing strategy to overcome this relative ATRA resistance, we investigated the potency of the HDAC class-I selective inhibitor entinostat in AML cell lines Kasum...

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Bibliographic Details
Main Authors: Nadja Blagitko-Dorfs, Yi Jiang, Jesús Duque-Afonso, Jan Hiller, Arzu Yalcin, Gabriele Greve, Mahmoud Abdelkarim, Björn Hackanson, Michael Lübbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3792939?pdf=render

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http://europepmc.org/articles/PMC3792939?pdf=render

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