Uridine modulates monoclonal antibody charge heterogeneity in Chinese hamster ovary cell fed-batch cultures
Abstract Background Charge heterogeneity is one of the most critical quality attributes of antibodies, which has strong influence on drug’s biological activity and safety. Finding out the key components that affecting charge variants is of great significance for establishing a competitive culture pr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2018-09-01
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| Series: | Bioresources and Bioprocessing |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40643-018-0228-2 |