Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction

Preparation of neuroprotective condensed 1,4-benzoxazepines by regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction

Condensed O,N-heterocycles containing tetrahydro-1,4-benzoxazepine and tetrahydroquinoline moieties were prepared by a regio- and diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization reaction of a 4-aryl-2-phenyl-1,4-benzoxazepine derivative obtained from flavanone. The relative con...

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Bibliographic Details
Main Authors: László Tóth, Yan Fu, Hai Yan Zhang, Attila Mándi, Katalin E. Kövér, Tünde-Zita Illyés, Attila Kiss-Szikszai, Balázs Balogh, Tibor Kurtán, Sándor Antus, Péter Mátyus
Format: Article
Language:English
Published: Beilstein-Institut 2014-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
1,4-benzoxazepine
diastereoselective domino Knoevenagel–[1,5]-hydride shift cyclization
neuroprotective
tert-amino effect
TDDFT-ECD calculation
Online Access:https://doi.org/10.3762/bjoc.10.272

Internet

https://doi.org/10.3762/bjoc.10.272

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