Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides

Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity. We therefore systematically evaluated several synthetic strategies to increase the stability and or...

Full description

Bibliographic Details
Main Authors: Volker Herzig, Aline Dantas de Araujo, Kathryn P. Greenwood, Yanni K.-Y. Chin, Monique J. Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham M. Nicholson, Paul F. Alewood, Glenn F. King
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Biomedicines
Subjects:
insecticidal
spider venom peptide
ω-HXTX-Hv1a
oral bioavailability
diselenide bond
cyclization
selenocysteine
Online Access:http://www.mdpi.com/2227-9059/6/3/90

Internet

http://www.mdpi.com/2227-9059/6/3/90

Similar Items