Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

Abstract Background Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy resistant, and Neurofibromatosis type 1 associated neoplasia, shows a...

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Bibliographic Details
Main Authors: Christian Linke, Markus Wösle, Anja Harder
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
MPNST
NF1
3-BrPA
Glycolysis
Mitochondrial respiration
p53
Online Access:http://link.springer.com/article/10.1186/s12885-020-07397-w

Internet

http://link.springer.com/article/10.1186/s12885-020-07397-w

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