Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani

Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With Leishmania donovani

Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL diminish due to emerging drug resistance. Although the principal host cells for the multiplication of Leishmania are macrophages, neutrophils are the first cells infected with the parasites rapidly after p...

Full description

Bibliographic Details
Main Authors: Mareike Ohms, Carolina Ferreira, Hauke Busch, Inken Wohlers, Ana Cristina Guerra de Souza, Ricardo Silvestre, Tamás Laskay
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
neutrophils
glucose metabolism
glycolysis (glycolytic pathway)
oxidative phosphorylation (OXPHOS)
leishmania
host-directed therapy (HDT)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632512/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.632512/full

Similar Items