TTF-1/p63-Positive Poorly Differentiated NSCLC: A Histogenetic Hypothesis from the Basal Reserve Cell of the Terminal Respiratory Unit

TTF-1/p63-Positive Poorly Differentiated NSCLC: A Histogenetic Hypothesis from the Basal Reserve Cell of the Terminal Respiratory Unit

TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6, p63 and p40 are useful for typifying the majo...

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Bibliographic Details
Main Authors: Daniela Cabibi, Sandro Bellavia, Antonino Giulio Giannone, Nadia Barraco, Calogero Cipolla, Anna Martorana, Vito Rodolico, Massimo Cajozzo, Ada Maria Florena
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Diagnostics
Subjects:
nsclc
non-small-cell lung cancer
histogenetic hypothesis
ttf-1
p63
basal reserve cells
terminal respiratory unit
Online Access:https://www.mdpi.com/2075-4418/10/1/25

Internet

https://www.mdpi.com/2075-4418/10/1/25

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