Inhibition by Zn2+ of A-form Monoamine Oxidase in Monkey Brain Mitochondria

The effects of ZnSO4 on mitochondrial monoamine oxidase (MAO) activity in monkey brain were compared with those in rat and rabbit, in vitro. After preincubation at 25°C for 20 min with 1 μM ZnSO4, MAO-A activity in monkey brain was about 50% using serotonin (5-HT) as a substrate, and the inhibition...

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Bibliographic Details
Main Authors: Toru Egashira, Fusako Takayama, Kumiko Sakai
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319327392