Mizoribine as Sole Immunosuppressive Agent in Islet Xenotransplantation Models: A Candidate Immunosuppressant Causing no Adverse Effects on Islets

Mizoribine as Sole Immunosuppressive Agent in Islet Xenotransplantation Models: A Candidate Immunosuppressant Causing no Adverse Effects on Islets

Mizoribine (MZ) inhibits the differentiation and proliferation of helper T and B cells after antigen recognition by suppressing the purine biosynthesis pathway and nucleic acid synthesis. MZ has been used in kidney transplantation, but distinct data are unavailable for islet transplantation. The pre...

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Bibliographic Details
Main Authors: Michitoshi Yamashita, Takuro Saito, Kazuya Ise, Show Ishii, Yoshihiro Satoh, Takaharu Saito, Ikuro Oshibe, Hirofumi Shimizu, Akira Kenjo, Takashi Kimura, Mitsukazu Gotoh M.D.
Format: Article
Language:English
Published: SAGE Publishing 2012-03-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368911X605457

Internet

https://doi.org/10.3727/096368911X605457

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