Mizoribine as Sole Immunosuppressive Agent in Islet Xenotransplantation Models: A Candidate Immunosuppressant Causing no Adverse Effects on Islets
Mizoribine (MZ) inhibits the differentiation and proliferation of helper T and B cells after antigen recognition by suppressing the purine biosynthesis pathway and nucleic acid synthesis. MZ has been used in kidney transplantation, but distinct data are unavailable for islet transplantation. The pre...
Main Authors: | Michitoshi Yamashita, Takuro Saito, Kazuya Ise, Show Ishii, Yoshihiro Satoh, Takaharu Saito, Ikuro Oshibe, Hirofumi Shimizu, Akira Kenjo, Takashi Kimura, Mitsukazu Gotoh M.D. |
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Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2012-03-01
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Series: | Cell Transplantation |
Online Access: | https://doi.org/10.3727/096368911X605457 |
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