Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Enriched gestation activates the IGF pathway to evoke embryo-adult benefits to prevent Alzheimer’s disease

Abstract Background Building brain reserves before dementia onset could represent a promising strategy to prevent Alzheimer’s disease (AD), while how to initiate early cognitive stimulation is unclear. Given that the immature brain is more sensitive to environmental stimuli and that brain dynamics d...

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Bibliographic Details
Main Authors: Enjie Liu, Qiuzhi Zhou, Ao-Ji Xie, Mengzhu Li, Shujuan Zhang, Hezhou Huang, Zhenyu Liuyang, Yali Wang, Bingjin Liu, Xiaoguang Li, Dongsheng Sun, Yuping Wei, Xiaochuan Wang, Qun Wang, Dan Ke, Xifei Yang, Ying Yang, Jian-Zhi Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Translational Neurodegeneration
Subjects:
Alzheimer’s offspring
Brain-derived neurotrophic factor
Gestational environment enrichment
Histone acetyltransferase
Insulin-like growth factor 1 receptor
Online Access:http://link.springer.com/article/10.1186/s40035-019-0149-9

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http://link.springer.com/article/10.1186/s40035-019-0149-9

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