MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling

Abstract Background The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) and III (λ) interferon (IFN) signalling. Dual specificity mitogen-activa...

Full description

Bibliographic Details
Main Authors: Engin Baturcam, Stefan Vollmer, Holger Schlüter, Rose A. Maciewicz, Nisha Kurian, Outi Vaarala, Stephan Ludwig, Danen Mootoosamy Cunoosamy
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Cell Communication and Signaling
Subjects:
Human rhinovirus
Respiratory syncytial virus
Innate immune response
Interferon-β
Interferon stimulated genes
Dual specificity mitogen-activated protein kinase kinase (MEK) pathway
Online Access:http://link.springer.com/article/10.1186/s12964-019-0378-7

Internet

http://link.springer.com/article/10.1186/s12964-019-0378-7

Similar Items