PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been reported in peripheral lymphocytes of MS patients. Mitoc...

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Bibliographic Details
Main Authors: Domenico De Rasmo, Anna Ferretta, Silvia Russo, Maddalena Ruggieri, Piergiorgio Lasorella, Damiano Paolicelli, Maria Trojano, Anna Signorile
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomedicines
Subjects:
multiple sclerosis
PBMCs
mitochondria
ROS
OPA1
PHB2
Online Access:https://www.mdpi.com/2227-9059/8/4/85

Internet

https://www.mdpi.com/2227-9059/8/4/85

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