The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi

The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi

In this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-I:β-CD were 10 times more active than MTZ, demonstra...

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Bibliographic Details
Main Authors: Marcela Silva Lopes, Policarpo Ademar Sales Júnior, Amanda Gervásio Ferreira Lopes, Maria Irene Yoshida, Thais Horta Alvares da Silva, Alvaro José Romanha, Ricardo José Alves, Renata Barbosa de Oliveira
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2011-12-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
nitroaromatic
cyclodextrin
Chagas disease
Trypanosoma cruzi
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800027&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000800027&lng=en&tlng=en

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