The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.

The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.

BACKGROUND:Breast cancer (BrCa) is a complex disease driven by aberrant gene alterations and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation also plays an important role in its pathogenesis. Ubiquitin carboxyl- terminal esterase L1 (UCHL1) is a tumor suppressor...

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Bibliographic Details
Main Authors: Tingxiu Xiang, Lili Li, Xuedong Yin, Chenfu Yuan, Cui Tan, Xianwei Su, Lei Xiong, Thomas C Putti, Michael Oberst, Kathleen Kelly, Guosheng Ren, Qian Tao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261155?pdf=render

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http://europepmc.org/articles/PMC3261155?pdf=render

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